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Search Results for " hepatic steatosis "

17

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TD0093	Oil Red O	Others	Others
	Oil Red O 用于制备染色溶液，可用于检测组织学冷冻切片中的脂质。
T12580	PTUPB	COX; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Neuroscience
	PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。
T60033	SBI993	Others	Others
	SBI993 是 SBI-477 的类似物，可用作生物标志物来确认 MondoA 靶基因在体内表达的预期作用。 SBI993 降低肌肉 TAG 水平和肝脂肪变性。
T15779	LP-533401 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	LP-533401 hydrochloride 是不能穿过血脑屏障的外周 Tph 抑制剂，抑制5-羟色胺合成，可用于研究牙周病和肝脂肪变性。
T60004	SRI-37330	Others	Others
	SRI-37330 抑制胰高血糖素的分泌和功能，减少肝葡萄糖的产生，并逆转肝脂肪变性。
T23097	O-1602 O1602,O 1602	Cannabinoid Receptor; Calcium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	O-1602 是一种新型 GPR55 激动剂，是一种非典型大麻素，与中枢神经系统和肥胖有关，是治疗膀胱炎的候选化合物。O-1602通过小鼠GPR55 的 PI3激酶/ Akt / SREBP-1c信号传导促进肝脂肪变性。O-1602以GPR3非依赖性方式诱导Hep55B细胞中的细胞内钙升高。
T9186	Ervogastat PF-06865571	Transferase	Metabolism
	Ervogastat (PF-06865571) 是一种有效且耐受性良好的二酰基甘油酰基转移酶 2 抑制剂。 Ervogastat 可降低非酒精性脂肪性肝炎 (NASH) 中的脂肪变性和肝脏甘油三酯水平。
T77245	Mannan	Endogenous Metabolite	Metabolism
	Mannan 是从藻类、蘑菇、酵母和高等植物中分离出的，可作为免疫调节剂。Mannan 抑制肝脏巨噬细胞（M1谱系）的促炎活性对许多肝脏病变（例如坏死或脂肪变性）具有保护作用。
T68974	MHY553
	MHY 553 is a PPARα agonist that improved aged-induced hepatic steatosis.
T36860	C22 Sphingomyelin (d18:1/22:0) C22 Sphingomyelin (d18:1/22:0)
	C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。
T35636	SHS4121705
	SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as effic...
T35441	Tripalmitolein
	Tripalmitolein is a triacylglycerol that contains palmitoleic acid at the sn-1, sn-2, and sn-3 positions. It reduces red blood cell deformability in a concentration-dependent manner in a Reid's filtration assay. Hepatic levels of 1,2,3-tripalmitoleoyl-rac-glycerol are increased in the JAK2L mouse model of hepatic steatosis. Tripalmitolein plasma levels are decreased in renal patients before dialysis.
T72889	FXR agonist 4
	FXR agonist4，一种法尼酯X受体(FXR)激动剂，具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症，因此可用于非酒精性脂肪性肝病(NAFLD)的研究。
T35444	1-Pentadecanoyl-rac-glycerol
	1-Pentadecanoyl-rac-glycerol is a monoacylglycerol that contains pentadecanoic acid at the sn-1 position. It has been found in wheat bran extracts.1 1-Pentadecanoyl-rac-glycerol levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate.2 \|1. Prinsen, P., Gutiérrez, A., Faulds, C.B., et al. Comprehensive study of valuable lipophilic phytochemicals in wheat bran. J. Agric. Food Chem. 62(7), 1664-1673 (2014).\|2. Brown, M.V., Compton, S.A., Milburn, M...
T64144	FXR antagonist 1
	FXR antagonist 1 是一种选择性的、口服具有活力的肠道 FXR 拮抗剂，其 IC50 值为 2.1 μM。FXR antagonist 1 能够拮抗肠道 FXR，并反馈激活肝脏 FXR，进而选择性地抑制肠道 FXR 信号。FXR antagonist 1 可改善 NASH (非酒精性脂肪性肝炎) 模型中的肝脏脂肪变性、炎症和纤维化，能够用于研究 NASH。
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...

化合物

Cat.No: TD0093

Target: Others

Cat.No: T12580

Target: COX, Epoxide Hydrolase

Cat.No: T60033

Target: Others

LP-533401 hydrochloride

Cat.No: T15779

Target: 5-HT Receptor

Cat.No: T60004

Target: Others

Cat.No: T23097

Synonym: O1602,O 1602

Target: Cannabinoid Receptor, Calcium Channel

Cat.No: T9186

Synonym: PF-06865571

Target: Transferase

Cat.No: T77245

Target: Endogenous Metabolite

Cat.No: T68974

C22 Sphingomyelin (d18:1/22:0)

Cat.No: T36860

Synonym: C22 Sphingomyelin (d18:1/22:0)

Cat.No: T72034

Target: Others

Cat.No: T35636

Cat.No: T35441

Cat.No: T72889

1-Pentadecanoyl-rac-glycerol

Cat.No: T35444

FXR antagonist 1

Cat.No: T64144

Cat.No: T35816

Cat. No.	Product Name	Target	Signaling Pathways
T7992	4-Hydroxyflavanone	NO Synthase	Immunology/Inflammation
	4-Hydroxyflavanone 是一种黄酮的合成类似物，是 SREBP 成熟和脂质合成的抑制剂。它具有研究肝脏脂肪变性及血脂异常的潜力。
T3888	Scopolin Murrayin,东莨菪甙,Scopoloside,东莨菪苷	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Scopolin (Scopoloside) 是从拟南芥根中分离出来的香豆素，可通过激活SIRT1介导的信号级联反应减轻了肝脂肪变性。
T0746	Orotic acid 乳清酸,Vitamin B13,6-Carboxyuracil	Nucleoside Antimetabolite/Analog; Dehydrogenase; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Orotic acid (Vitamin B13) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
T3271	Orotic acid zinc 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate	Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Orotic acid zinc (Zinc Orotate) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
TN6751	1-HEXACOSANOL	NPC1L1; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	1-HEXACOSANOL 激活 AMPK 和肝脏自噬并抑制 SREBP2，导致降胆固醇活性和肝脏脂肪变性的改善。
T6S0221	Eriocitrin eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙；圣草次苷,Eriodictyol glycoside	Apoptosis; Carbonic Anhydrase	Apoptosis; Metabolism
	Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物，是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞，从而抑制肝癌细胞的增殖。
T30784	Cedrene AI3-51328,AI3 51328,AI351328
	Cedrene can regulate hepatic steatosis via the cAMP-PKA pathway.
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

4-Hydroxyflavanone

Cat.No: T7992

Target: NO Synthase

Cat.No: T3888

Synonym: Murrayin,东莨菪甙,Scopoloside,东莨菪苷

Target: Sirtuin

Cat.No: T0746

Synonym: 乳清酸,Vitamin B13,6-Carboxyuracil

Target: Nucleoside Antimetabolite/Analog, Dehydrogenase, Endogenous Metabolite

Orotic acid zinc

Cat.No: T3271

Synonym: 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Cat.No: TN6751

Target: NPC1L1, AMPK

Cat.No: T6S0221

Synonym: eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙；圣草次苷,Eriodictyol glycoside

Target: Apoptosis, Carbonic Anhydrase

Cat.No: T30784

Synonym: AI3-51328,AI3 51328,AI351328

Cat.No: T35624

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